Associate Principal Scientist/Associate Director - Antibody Drug Conjugation

Gaithersburg, Maryland

Posted in Pharmaceuticals

Job Info


Are you a highly motivated Associate Principal Scientist/Associate Director -with expertise in Antibody Drug Conjugation? If so, do you want to join the team at AstraZeneca Oncology, with a vision for redefining cancer, redefining our solutions to cancer and restoring patients' lives!

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a Senior Scientist in Oncology R&D in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.

In this role, you will be part of a team of highly skilled and passionate individuals responsible for innovating and generating the best in class antibody drug conjugates for various therapeutic areas. We are seeking a highly motivated conjugation scientist with a background in drug discovery. Exciting opportunity to lead and contribute to multi-disciplinary drug development.

Main Duties & Responsibilities:

  • Managing and mentoring a team of conjugation scientists to deliver platform and pipeline focused drug conjugates for oncology and other therapeutic areas.
  • Coordinate, align and plan conjugation workflow within a larger team.
  • Conjugation, purification and characterization of mg to gram quantity of ADCs using multiple validated methodologies
  • Development and optimization of novel conjugation methodologies to improve ADC properties
  • Collaborate and work with a diverse group of scientists across many therapeutic areas, chemistry, and process development to ensure timely progress in research projects and drive technological innovations
  • Lead and coordinate laboratory maintenance, including maintenance of equipment and lab safety

  • Demonstrated extensive hands-on experience in the design and generation of antibody drug conjugates.
  • Working knowledge of characterization using analytical techniques like Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography-mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, etc.
  • Hands-on experience and knowledge of protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC preferred
  • Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines
  • Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset and maintains a detailed laboratory notebook
  • Track record of scientific innovation as evidenced by scientific publications, patents, and oral presentations at conferences
  • Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management

  • Experience managing multiple reports in an established conjugation lab and coordinating workflow is highly preferred.
  • Experience in protein engineering is a plus.
  • Experience working and coordinating with CROs.

  • Ph.D. in Organic Chemistry/ Chemical Biology/ Biochemistry or other relevant discipline with 5+ years of relevant experience - OR - Masters in Organic Chemistry/ Chemical Biology/ Biochemistry or other relevant discipline with 12+ years of relevant experience

So, what's next?

Are you already envisioning yourself joining our team? Good, because we can't wait to hear from you! If you are inspired by the possibilities, don't hesitate in submitting an application today!

Competitive remuneration and flexible benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

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