Lead Computational Chemist - Oncology R&D
Boston - US
At AstraZeneca, we turn ideas into life-changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life!
AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer and to ultimately eliminate cancer as a cause of death!
To succeed in this vision, AstraZeneca are seeking a computational chemist for our Oncology medicinal chemistry department based in Waltham, Massachusetts. The successful candidate will be a professional computational chemist, with a passion for drug discovery and experience of working in drug discovery project teams within a biotech or pharmaceutical setting. You will be working closely with an established, transnational team of computational chemists within AstraZeneca working on oncology drug discovery projects across a range of modalities and will have access to state-of-the-art computational methods, such as our FEP and AI platforms, and excellent lead generation capabilities.
Does this sound like you? if so...we are keen to speak with you.
As a leading member of the medicinal chemistry design team, you will be responsible for:
Setting and delivering on computational and medicinal chemistry strategies to impact project success at all stages from drug target identification through to clinical candidate nomination.
Working with a high degree of independence, you will carry out structure- and ligand-based design and data analysis, extracting insight from large proprietary structural biology and SAR data sets; your contributions to molecular design will be expected to result in inventorship on patent applications.
You will work closely with scientists from other disciplines including structural biology, biophysics, ADME/DMPK and safety sciences as part of the wider drug discovery project team, and will present your work regularly to peers and senior partners. Depending on experience and interest, you might also function as the lead chemist for a drug discovery project.
At AstraZeneca, we value scientific innovation. Maintaining an awareness of the current state-of-the art, you will identify promising new computational methodologies or technologies that could benefit drug discovery, and will develop and implement these through internal or external collaborations, sharing best practice across AstraZeneca. You will be expected to publish your work regularly in high quality scientific journals and at national and international conferences.
You'll have the opportunity to build academic collaborations and to supervise graduate scientists and postdocs, as well as to mentor colleagues. The scope for personal development is vast.
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