Process Chemistry Scientist I
Vertex Pharmaceuticals Inc (US)

Job Info

Vertex is seeking an organic chemist to join the Process Chemistry Automation Lab, a recently established group within Process Chemistry. The successful candidate will have a unique opportunity to help build our state-of-the-art automation laboratory. As a member of the team, they will work collaboratively to develop safe, efficient, and robust synthetic routes to drug candidates.

Key Responsibilities

• Independently design and execute high throughput experimentation (HTE) using laboratory automation to solve process chemistry problems

• Develop new workflows with automation robotics, such as liquid handlers, solid handlers, high throughput analytical systems, and integrated robotic platforms

• Clearly communicate HTE results to stakeholders using multi-dimensional data analysis tools (e.g. JMP, Spotfire)

• Identify broad implications of data capture and data mining from HTE

• Identify and advocate for innovative automation strategies to project teams

• Provide training on automation equipment and HTE

• Maintain laboratory automation equipment and develop new protocols

• Collaborate with project teams in a cross-functional environment

• Author or contribute to technical documents including regulatory submissions, patents, and scientific papers

• Maintain a high level of expertise via relevant scientific and technical literature, and proactively apply new ideas to research projects.

• Multitasks to effectively manage multiple activities/projects.

Minimum Qualifications

• PhD (0+) or MS (4+) in synthetic organic chemistry

• Experience independently planning, executing experiments, and interpreting analytical data (H/UPLC, NMR, MS, etc.)

• Strong expertise in organic synthesis

• Experience with any of the following: high throughput experimentation, laboratory automation (i.e. Chronect/QX96, Chemspeed, Unchained Labs, Hamilton, Tecan, etc.), biocatalysis, flow chemistry, cheminformatics, Python, reaction kinetic analysis

• Strong organizational and communication skills

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