Scientist, Bioscience Oncology
AstraZeneca

Job Info

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Scientist, Bioscience Oncology

Location - Waltham, Massachusetts (Boston)

Do you have expertise in, and passion for oncology research? Would you like to apply your expertise to impact drug development in a company that follows the science and turns ideas into life changing medicines? Then employment at AstraZeneca might be the right choice for you!

What is Happening at AstraZeneca

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

This Opportunity

We are seeking a highly motivated Scientist in Targeted Tumor Delivery with deep scientific and technical expertise in antibody/antibody-drug conjugate therapeutics with a track record of scientific excellence to join our team in Waltham, MA USA. As a Scientist in our Oncology R&D department you will be a key member of a team focused on supporting oncology projects through the drug discovery and development process. You will bring your theoretical and practical expertise in cancer biology to establish assay systems and deliver datasets that will have direct impact on targeted therapeutics.

Responsibilities:

You will work in a laboratory within the Oncology Research group designing, conducting and analyzing in vitro and in vivo experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.

Essential Requirements

• Bachelors or Masters degree in tumor biology or a related field
  
• Depth of understanding for hematology cancer models as well as solid tumor models
  
• Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, high-content imaging, and cell death measurement in primary and cell line cultures)
  
• Experience conducting multi-spectral flow cytometry and visualizing/quantitating high content multi-parameter flow data
  
• Molecular biology skills including assessment of intracellular signaling and generation of engineered cell lines, generating and/or analyzing transcriptomic data
  
• Strong interpersonal and collaboration skills together with evidence of having used these to support problem solving and delivery in a collaborative environment.
  

Desirable Requirements

• Experience in the evaluation of immune function and in the application of complex immunological assays
  
• Experience working with cell death modulating agents, with biologics including antibodies and antibody-drug conjugates and evaluation of transcriptomic datasets
  
• Familiarity with nano-medicine drug delivery
  
• Knowledge of the drug discovery process and publications in credible scientific journals
  

Oncology Vision

AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused on bringing novel concepts in immuno-oncology to unmet medical need.

About AstraZeneca in Waltham, MA

The Waltham R&D site focuses on our small-molecule oncology research in North America, and is situated within a biopharma cluster of research institutions, medical centers, pharmaceutical companies and startups. The Boston region is consistently ranked #1 globally for research, investment, talent recruitment and lab space. The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking, with charging stations now available for electric vehicles, and shuttle service to local transportation hubs. So, what's next! Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Don't hesitate in submitting an application today, or get in touch with our Talent Acquisition Partner - Suzanne Bellomo, to arrange a confidential discussion to explore this opportunity further.

Why AstraZeneca?

At AstraZeneca we're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. We foster an inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

So, what's next?

• Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!
  

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight.

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