The Upstream Process Development - Biopharmaceuticals team in Zoetis Veterinary Medicine Research and Development is seeking a motivated bioprocess scientist or engineer to propel an exciting portfolio of novel protein therapeutics and monoclonal antibodies designed for veterinary medicine applications. As a member of this team, the successful candidate would work hands-on at the bench to develop mammalian cell culture production processes in bioreactors to improve productivity, product quality, robustness, and economics. Upon being trained, the successful candidate would work with a large degree of autonomy to design and execute experiments and be responsible for maintaining project timelines. To successfully develop processes, the candidate would apply knowledge of the biological sciences, relevant bioprocess technologies, and process scaling, while collaborating directly with scientists across Research, Development, Pilot plants, and Manufacturing. Furthermore, the successful candidate must also demonstrate growth in problem-solving, decision making, innovation, and capacity to learn a broad spectrum of skills to discover effective solutions for the numerous scientific challenges encountered during process development. Thus, candidates with proficiency in biopharmaceutical process development and related fields will be highly regarded. This position will be based in Kalamazoo, MI with interactions with colleagues and external partners located around the globe.
Represent upstream process development in multiple project teams by being accountable to timelines, clearly communicating research findings, and sharing subject matter expertise.
Collaborate directly with scientists in multiple adjacent development teams and pilot and manufacturing sites globally.
Apply theoretical knowledge in the scientific disciplines that support mammalian cell culture and biopharmaceutical production.
Design and conduct cell culture experiments in shake flasks and bioreactors to identify and validate parameters that affect performance, such as cell growth, product yield, and product quality.
Apply formal design of experiments and statistical models to systematically improve the parameters that affect cell culture and bioreactor performance.
Understand and apply principles of scale-up and scale-down to bioreactor systems ranging from micro-scale to bench-scale to large-scale.
Organize, manage, and interpret large data sets.
Document experimental findings and maintain electronic laboratory notebooks in accord with scientific protocol and applicable Standard Operating Procedures.
Author reports to be included in technology transfers and dossiers for product registration.
Drive innovation and continuous improvement by seeking and studying latest bioprocess technologies and techniques, as well as designing and conducting laboratory experiments to evaluate.
Preferred technical skills
Demonstrated aseptic cell culture technique for mammalian cell culture.
Independent upstream process development experience. Demonstrated success in applying knowledge such as, but not limited to, molecular biology, cellular metabolism, signal transduction pathways, biochemistry, biotechnology, and biochemical engineering to bioprocess development will be highly regarded.
Theoretical and applied knowledge of the parameters that affect bioreactor design, performance, and scaling. Experience in calculating multiple scaling parameters and computational fluid dynamics will be highly regarded.
Theoretical and applied knowledge of the latest bioprocess technologies, such as in-situ probes, metabolite analyzers, off-gas analyzers. Experience in process automation, process intensification, and continuous production will be highly regarded.
Theoretical and applied knowledge of design of experiment and statistics will be highly regarded, as well as experience in wrangling and interpreting large bioprocess data sets.
Excellent written and verbal communication.
Education and experience
Possess a relevant degree in science or engineering, such as Biochemistry, Molecular Biology, Cell Biology, Biotechnology, Chemical/Biochemical Engineering, or Biomedical Engineering.
A BS candidate would be expected to have 4+ years of experience and the MS candidate 2+ years of experience in a relevant biotechnology industry. PhD not required, though highly considered.
Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at firstname.lastname@example.org to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.
Posted about 20 hours ago
Posted about 20 hours ago
San Diego, California
Posted about 20 hours ago
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