Scientist, Translational Genomics, Oncology R&D
AstraZeneca

Job Info

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Scientist, Translational Genomics, Oncology R&D

Location: Waltham, US

Are you a highly motivated Scientist with a passion for Translational Genomics?

At AstraZeneca Oncology, we are not afraid to do things differently. Our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives. As a motivated Scientist, you will join a dynamic and collaborative team in our pioneering Biohub facility in Waltham MA.

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in pioneering ways, combining our people's exceptional skills with those of people from all over the globe. Does this sound like a team you would like to join?

Oncology Translational Medicine Genomics

The Translational Medicine function exists within Oncology R&D to ensure effective and strategic biomarker studies for oncology project teams. Closely interacting with the pre-clinical Discovery, Early Clinical Development, and Precision Medicine & Biosamples diagnostics functions, Translational Medicine is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all Oncology project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, delivery of translational science research and early clinical phase engagement.

The Global Genomics team within Translational Medicine function leverages Next Generation Sequencing (NGS) and other advanced technologies to match the right patient to the right drug and support precision oncology approaches for the AZ Oncology pipeline.

Major Responsibilities and Accountabilities

Within this role you will be responsible for executing work in a genomics lab - planning, designing, and performing experimental work, then documenting and communicating results to appropriate partners.

• Conceptualize, develop, and implement evaluations of platforms, vendors, and emerging technologies of translational utility.
• Develop and maintain internal genomics lab capability with a focus primarily on nucleic acid isolation, library construction and sequencing on Illumina instruments.
• Involvement in data analysis, trouble-shooting, interpretation of results, and communication back to project teams. Familiarity with instrumentation including automation and software necessary for a high-throughput genomics lab.
• Provide technical advice and genomic/biomarker consultation to internal and external partners
• Deliver multi-omics information to AZ project teams and other partners using NGS and other pioneering technologies.
• Deliver biomarker assays and genomic/molecular profiling datasets leveraging sample management software, a LIMS system, laboratory automation and project tracking tools.
• Where practical, collaborate with external partners for high-throughput sequencing, technology development, and other advanced genetics/genomics approaches.
• Work with Translational Medicine Leads to consult on technologies, develop project biomarker plans, and use fit-for-purpose platforms.
• Identify exploratory and clinically qualified biomarkers relevant for dose selection, dosing schedule, drug response/resistance, patient stratification, and disease progression.
• After qualifying relevant biomarkers, work in collaboration with diagnostic, clinical, and regulatory partners to develop companion diagnostics on internal and external projects.
• Maintain appropriate documentation in compliance with internal and external requirements. Create project reports clearly and concisely summarizing results in an electronic lab notebook.
• Lead and participate in external presentation of results and peer reviewed journal publications.

Minimum Requirements/Qualifications

• B.S./M.S. in a relevant science subject
• 2 years of experience within a Scientist position
• Experience with Next Generation Sequencing is required
• Experience working with plasma derived circulating/cell free DNA (cfDNA) is required
• Experience working with a LIMS and an electronic lab notebook would be advantageous
• Excellent oral and written communication skills
• Excellent problem-solving skills with a clear understanding of the balance of innovation, calculated risks, and project delivery
• Ability to multi-task in a fast-paced environment with changing priorities

So, what's next?

Are you already envisioning yourself joining our team? Good, because we can't wait to hear from you!

If you are inspired by the possibilities, don't hesitate in submitting an application today!

Closing date: July 1st 2022

Competitive Remuneration and benefits apply!

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more

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Why AstraZeneca

We are a global biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

About The Site

The Waltham R&D site is home to our small-molecule oncology research in North America, and is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech start-ups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space.

The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking, with charging stations now available for electric vehicles, and shuttle service to local transportation hubs.

Pymetrics Assessment

As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight.

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants. COVID-19 vaccination is required for all US employees, and weekly PCR COVID-19 testing is required for those who are unvaccinated or have an approved accommodation.

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