Senior Scientist, ADC Programs, Early Oncology Discovery
AstraZeneca

Job Info

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At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers.

We are seeking a highly motivated and independent Senior Scientist with a proven track record of scientific excellence in cancer biology to join our antibody-drug conjugates (ADCs) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA. As a Senior Scientist, you will be a key member of a team focused on bringing new ADC projects into the portfolio and advancing them through all stages of pre-clinical development. You will have a direct impact on the drug discovery process, a hands-on contributor in the lab. You will bring your theoretical and practical expertise to support pipeline projects, establishing program priorities and working with a cross-functional team to deliver pre-clinical datasets to support pipeline progression. You will present program updates at internal meetings. As part of the team, you will also make intellectual contributions to programs across the ADC Portfolio.

Main Duties and Responsibilities

• You will serve as Oncology biology support one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable milestone progression decisions.
• Working with the project team, you will help set program strategy, and as biology lead you will be responsible for the delivery of key pre-clinical data that support a strong biological rationale for program progression.
• Working in the laboratory, you will develop, design, conduct, troubleshoot, and analyze in vitro experiments to assess the function of our ADCs and dissect the mechanism of action of these novel cancer therapeutics.
• As a highly organized, self-motivated individual with a strong background in cancer biology, you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to antibody drug conjugates, and have a genuine passion for this field of research.

Essential Requirements

• PhD Degree with 3+ years of experience, Master's Degree with 5+ years of experience
• Strong knowledge of cell biology, molecular biology, and/or biochemistry in the context of cancer biology, with a strong desire for continued learning.
• Works independently to design and conduct key experiments to support program progression. Experience with molecular- and cell-based methodologies such as cytotoxicity assays, flow cytometry, fluorescent and live cell microscopy, ELISA, qPCR, western blotting.
• Excellent communication, presentation, and interpersonal skills and evidence of delivery in a team-oriented, collaborative environment.
• A proven track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals.
• Ensures own work, and work of peers, follows Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Desirable Requirements

• Prior experience in the biopharmaceutical industry preferable but not required.
• Hands on experience with pre-clinical in vivo models of cancer would be viewed favorably.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering innovative methods and bringing unexpected teams together. Interested? Come and join our journey.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

So, what's next!

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazeneca/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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