Senior Scientist - Mass Spec Protein Characterization

Gaithersburg, Maryland

Posted in Pharmaceuticals
about 1 month ago

This job has expired.

Job Info

Senior Scientist - Mass Spec Protein Characterization

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As apart of our Protein Engineering team inGaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.

AstraZeneca has an opening for a Senior Scientist in the Cell Therapy group to support pre-clinical research of innovative therapeutic products. The main duties for the ideal candidate are to help build a CAR-T platform to support AstraZeneca's regenerative cell therapy pipeline projects.

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

The Cell Therapeutics Technology group within the Antibody Discovery and Protein Engineering Department develops gene and cell therapy technologies and supports pre-clinical research of innovative therapeutic products. You will work as member of the expanding Dynamic Omics group and be actively involved in developing and implementing pipelines for metabolomics and proteomics applications to support the analysis of preclinical and clinical samples for Cell Therapy.

Main Duties & Responsibilities

Given the scope of this dynamic role and the need to multitask, it is essential to be a fast learner, excellent communicator, well-organized, innovative and able to work independently when designing and executing experiments as well as to manage and prioritize tasks. Furthermore, you should demonstrate enthusiasm, motivation, attention to detail and willingness to learn new technologies, flexibility and confidence. The job is highly complex, requiring a deep understanding of protein and peptide mass spectrometry, antibody structure, protein biochemistry, and data analyses.

  • Plan and execute characterization of antibodies and other proteins to support additional goals within ADPE, including mass spec analysis of developability concerns.
  • Design and execute of experiments to support discovery efforts across our different omics and cell therapy technologies, and supervise or train associate scientists on a project basis to assist in these experiments.
  • Analyze and interpret analytical data, and contribute to experimental plans; maintain accurate records of data and actively participate in laboratory organization.

Education & Experience Requirements
  • Ph.D. in biochemistry, chemical/biochemical engineering, or related field with 0-2 years of relevant laboratory experience

Required Skills
  • Protein characterization by intact and peptide mass spectrometry, including MS/MS.
  • Protein PTM discovery and quantitation by mass spectrometry
  • Ability to troubleshoot and collaboratively resolve complex problems under tight time constraints.
  • Good oral and written communication skills; Team player and customer-focused

Desired Skills
  • FPLC purification of proteins at multi-milligram scale, including affinity, ion-exchange, and size-exclusion chromatography.
  • Antibody structure, characterization and Fab cleavage methods.
  • Biochemical separations such as immunoprecipitation and affinity purification in the context of mass spectrometry analysis.
  • Protein/protein complex size characterization by SEC-MALS.
  • Octet or Biacore binding measurements.
  • Enzyme kinetics.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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