Senior Scientist - NMR Center in Structural Biology
St. Jude Children's Research Hospital

Job Info

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Overview

The St. Jude Children’s Research Hospital (St. Jude) Biomolecular NMR Center seeks to recruit an NMR expert at the Senior Scientist level. The Department of Structural Biology of St. Jude has two major ongoing projects requiring NMR investigations: seeing the invisible states in protein kinases and studying the mechanisms of biomolecular phase separation. Preferred skills and experiences:

Extensive experience in operating Bruker NMR spectrometers;Extensive knowledge and proficiency in NMR data processing using NMRPipe and analysis using Sparky or CARA;Extensive experience in applying NMR techniques to characterizing the structure and dynamics of large proteins, using both manual and automated backbone and methyl resonance assignment methodologies; Experience in performing and analyzing protein dynamics using the CEST and CPMG NMR methods;Familiar with NMR-based 3D structure calculation and refinement;Independently motivated, detail oriented and good problem-solving ability;Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment; Excellent communications skills and working in collaboration with other scientists; The NMR Senior Scientist will mainly perform NMR-related research, but experience with maintenance of Bruker NMR spectrometers or the willingness to learn and perform maintenance in the future, is highly desired.

Responsibilities

The NMR Senior Scientist will support studies of protein dynamics using sophisticated NMR relaxation methods, with focus on protein kinases. The kinase project utilizes ultra-high field NMR spectroscopy methods and biochemical characterization developed by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and dissect the mechanisms of allosteric regulation specifically underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, six 800 MHz, one 850 MHz, and the first 1.1 GHz NMR spectrometers and two Helium recovery systems. The new staff member will be involved in NMR studies to determine 3D structures and analyze dynamics features of multiple human kinases.
Minimum Education

Bachelor's degree in relevant scientific area is required

PhD strongly preferred

Minimum Experience

Ten (10) years relevant post-degree work experience is required

Eight (8) years of relevant post-degree work experience is required with a Master's degree

Six (6) years of relevant post-degree work experience is required with a PhD

Other Information

St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.COVID-19 vaccine:St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s ‘100 Best Places to Work’ for companies with 1,000 or more employees. We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. 49301

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