Title: Sr Scientist In Vivo - Dermatology
Full Time/Direct Hire Opportunity
Location: Mountain View, CA (relocation package available)
Start Date: ASAP
No C2C/Corp-to-Corp
Must be authorized to work in US without restriction or sponsorship
Responsibilities:
* Independently design, execute and analyze experiments and drive translational research
* Maintain and communicate findings effectively and clearly in a timely fashion
* Collaborate with other teams and team members to assess and understand data and disease models
* Perform specialized functional assay skills in tissue-specific models and experience working with various skin cells (generation, maintenance, differentiation, and validation)
* Evaluation of drug delivery, transfection efficiency, and therapeutic efficacy in dermatologic ex vivo and in vivo models using various imaging platforms and clinically relevant assessments
* In vivo injections of cells or solutions into local tissues - intradermal, subcutaneous, intramuscular etc.
* Use a variety of biochemical, cellular, genetic, and pharmacological techniques to advance multiple candidates from discovery research to clinical development
* Performance of cell-based assays and analytical techniques including qPCR, ELISA, western blotting, imaging, immunocytochemistry, immunofluorescence microscopy, flow cytometry, FACS, etc.
* Establishment and maintenance of cell and tissue culture model systems
* Mentor and manage 2-3 research assistants and/or laboratory technicians
* Development, validation, and writing of laboratory protocols, technical reports, abstracts, posters and scientific papers and presentations
* Development and application of established and novel ex vivo and in vivo model systems, particularly including the use of 3D human skin organoids and human skin explants
* Specialized functional cell assays specific to designated indication areas
* Development of specialized functional cell and tissue assays in wound healing, angiogenesis, extracellular matrix, and stem cell niche compartments
* Live animal imaging and simple biodistribution and safety measurements
* Specialized tissue functional assays specific to target indication(s)
Skills:
* PhD in cellular biology, biochemistry, molecular biology, or related discipline
* 7-10 years of extensive industry experience in dermatology-related translational research
* Experience in small (rodent) animal handling and tissue evaluation
* Experience in cell and tissue culturing and in vitro assays
* Experience mentoring and managing in the laboratory setting
* Autonomous execution capacity
* Collaboration with team members and across company programs
* Excellent verbal and written communication skills
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