Stem Cell Research Associate II
Vertex Pharmaceuticals Inc (US)

Cambridge, Massachusetts

Posted in Retail


This job has expired.

Job Info


In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat-and even cure-several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex's continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

Vertex seeks a talented scientist to join the Vertex Cell and Genetic Therapies (VCGT) stem cell research group in Cambridge, MA. The group's mission is to discover and actualize the next generation of cell therapies for diabetes. We are looking for a candidate with an interest in stem cell culture, developmental biology, and familiarity with analytical methods in cellular & molecular biology to support research efforts in these areas. The candidate will work closely with our scientists on discovery projects advancing our capabilities in pluripotent stem biology. The ideal candidate is scientifically independent and accustomed to taking initiative. The position requires strong communication and organization skills, but also proven adaptability and multitasking capability.

Key Responsibilities:

  • Perform human pluripotent stem cell culture and support discovery research efforts in stem cell biology.

  • Utilize analytical tools to evaluate molecular characteristics during pluripotent stem cell culture and differentiation.

  • Follow protocols and contribute to stem cell differentiation campaigns (periodic weekend work is required).

  • Work with cross-functional teams to plan, coordinate, and execute experiments.

  • Present findings to group and broader T1D teams, summarize data into reports for supervisor.

  • Assist with lab management: track cell culture reagents, place orders, prepare media and reagents, continuously work to improve lab operations.

Scientific and Non-scientific Skills:

  • Pluripotent stem cell culture experience (e.g., hESC and/or hiPSC). 2D culture experience is required, and 3D is desirable.

  • Experience performing stem cell differentiation to any cell type is desirable but not required

  • Familiarity with cell-based assays such as flow cytometry, western blot, qPCR, ELISA, library prep (scRNA-seq, ChIP-seq, ATAC-seq), Crispr/Cas9

  • Must possess critical thinking and self-reliance to solve tasks independently or ask questions.

  • Successful candidate will have outstanding organization and multitasking capability.

  • Candidate must possess flexibility to quickly pivot as projects demand.

  • The candidate will be accustomed to effectively communicating progress, needs, and problems.

Preferred Education and Experience Levels:

  • BS Biology or related field and 1-2+ years of relevant experience

#LI-KW1


This job has expired.

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